● 2004　Ph.D., Nuclear Science and Technology, Tsinghua University, P.R.China   Dissertation: Studies on System Modeling and Correction for Physical Factors in Single Photon Emission Computed Tomography

● 2001　Master of Engineering, Nuclear Science and Technology, Tsinghua University, P.R.China

●1999　Bachelor of Engineering, Engineering Physics, Tsinghua University, P.R.China

● 2019 - present　Tenured Associate Professor, Dept. of Engineering Physics, Tsinghua University.

● 2011 - 2019　Associate Professor, Dept. of Engineering Physics, Tsinghua University.

● 2006 - 2011　Assistant Professor, Dept. of Engineering Physics, Tsinghua University.

● 2008　Visiting fellow of Nuclear Medicine Physics, University at Buffalo, SUNY, USA

● 2006　Postdoctoral fellow of Nuclear Medicine Physics, Tsinghua University, P.R.China

● Courses：

2009 - present, Nuclear Medicine Instruments and Methods, Tsinghua University undergraduate course 80320262.

2010 - present, Nuclear Medicine imaging physics, Tsinghua University graduate course 40320262.

● Supervised Ph.D. Students (Graduated)：

2008 - 2013, Tiantian Dai, Medical Physicist at China-Japan Friendship Hospital

2009 - 2014, Jing Wu, Ph.D. Professor at Beijing Normal University

2010 - 2015, Tianpeng Xu, Ph.D. State Nuclear Security Technology Center

2010 - 2015, Hui Liu, Ph.D. Assistant Professor at Tsinghua University

2011 - 2016, Peng Fan, Ph.D. Senior Engineer at Beijing Institute of Spacecraft System Engineering

2011 - 2016, Zhenlei Lyu, Ph.D. Research Associate at Tsinghua University

2014 - 2019, Li Cheng, Ph.D. Postdoctoral Fellow at Tsinghua University

2015 - 2020, Qing Ye, Ph.D. Shanghai United Imaging Healthcare Co Ltd

2016 - 2021, Wenzhuo Lu, Ph.D. Boston Consulting Group

2014 - 2022, Rui Wang, Ph.D. Shanghai United Imaging Healthcare Co Ltd

2015 - 2023, Debin Zhang, Ph.D. Postdoctoral Fellowship in Tsinghua University

2016 - 2024, Yifan Hu, Ph.D. Postdoctoral Fellowship in Yale University

● Supervised Ph.D. Students (in Program)：

2020 - present, Yihang Zhu, Ph.D. Student

2021 - present, Linkang Liu, Ph.D. Student

2021 - present, Xingchun Zheng, Ph.D. Student

2022 - present, Linxin Lei, Ph.D. Student

2023 - present, Peize Li, Ph.D. Student

2023- present, Qiqi Ye, Ph.D. Student

2024- present, Yuxi Zhang, Ph.D. Student

PET and SPECT instrumentation; physics and detector development of radiation imaging systems; image reconstruction and analysis in emission computed tomography (ECT).

Research Grants：

1. “Development of Fast Cardiac Self-Collimating SPECT”, China Atomic Energy Authority Nuclear Technology Development Foundation, 240,000,000 RMB, PI.

2. “Development of Self-Collimating Imaging Systems”, National Technology Innovation Foundation, 690,000,000 RMB, PI.

3. “Development of hand-held self-collimation gamma camera for intraoperative applications”, National Technology Innovation Foundation, 179,400,000 RMB, PI.

4. “Development of high-resolution self-collimation gamma camera for bed-side diagnostic applications”, National Technology Innovation Foundation, 76,700,000 RMB, PI.

5. “Development of super-high resolution and super-high sensitivity self-collimation small SPECT”, Beijing Natural Science Foundation (No. Z220010), 3,000,000 RMB, PI.

6. “Development of high-resolution self-collimation gamma for molecular breast imaging”, Tsinghua

7. Precision Medicine Foundation, 200,000 RMB, PI.

8.“Development of self-collimation SPECT cameras for dual-head general-purpose clinical SPECT”, Tsinghua-Baoyuan Joint Institute for Particle Medicine, 44,560,000 RMB, PI.

9. “Development of super-high resolution self-collimation small SPECT”, Tsinghua University Initiative Scientific Research Program (Grant Number 20197010010), 2019 - 2023, 3,000,000 RMB, 2019 – 2022, PI.

10. “Development of hand-held and 3-D holographic gamma hotspot monitoring systems”, The National Key Research and Development Program of China (No. 2019YFF0302503), 4,800,000 RMB, 2019 – 2022, PI.

11. “On-line dosimetry monitoring in Proton Therapy”, The National Key Research and Development Program of China (No. 2016YFC0105405), 10,940,000 RMB, 2016 – 2020, co-PI

12. “Simultaneous PET and SPECT imaging”, National Natural Science Foundation of China (No. 11375096), 900,000 RMB, 2014-2017, PI

13. “Development of clinical SPECT system”, Novel Medical corp. 2011-2013, 5,000,000 RMB, PI

14. “Development of pre-clinical PET/SPECT CT system”, Novel Medical corp., 5,000,000 RMB, 2012-2013, co-PI

15. “Development of MR-compatible brain PET detectors”, Novel Medical corp., 4,000,000 RMB, co-PI

16. “Development and Simulation of SPECT imaging for the LYSO PET ring for the Mediso nanoScan PET/MRI”, Mediso Ltd. $25,000, 2011-2013, PI

● Engineering Leadership and Achievements：

1. 2010–2017: Served as Chief Technology Officer at Beijing Novel Medical Equipment Co., Ltd. Established and led a multidisciplinary R&D team of approximately 70 engineers. Directed the development and commercialization of:

（1）Animal PET/2010–2017:SPECT/CT systems (over 10 installations by 2025)

（2） Clinical SPECT systems (over 20 installations by 2025)

（3）Industrial gamma cameras for airport and border security (over 100 installations by 2025)

2. 2021–2024: Founded and led a 25-member engineering team at the Greater Bay Area National Center of Technology Innovation. Focused on the development of self-collimating gamma imaging systems, including animal and clinical SPECT devices. Achieved three notable installations by 2025:

（1）Self-collimating handheld gamma camera, installed at Fuwai Hospital, Chinese Academy of Medical Sciences, for imaging validation of novel myocardial blood flow tracers

（2）High-resolution clinical gamma camera, installed at China-Japan Friendship Hospital, for the diagnosis of hyperparathyroidism

（3）High-resolution small-animal SPECT, installed at The First Affiliated Hospital of Sun Yat-sen University, for preclinical imaging of ^131I- and ^177Lu-labeled therapeutic tracers.

● Book Chapters：

Yongjie Jin (Editor), Tianyu Ma(Co-Editor). Nuclear Medicine Instruments and Methods. Harbin Press, 2010, In Chinese.

● Invited Talks：

1. “A hybrid PET/SPECT small animal imaging system”, University of Texas MD Anderson Cancer Center, USA, Oct 14th , 2008.

2. “Towards better PET and SPECT: development of animal PET/SPECT and clinical PET scanners in Tsinghua”, Department of Biomedical Engineering, Yale University, USA, June 13th, 2014.

3. “Nuclear Medicine: Imaging nuclides, Saves lives”, July 28th, 2016, International Youth Nuclear Congress 2016.

4. “Detection, collimation and reconstruction – techniques in nuclear imaging chain and applications for imaging system instrumentations”, March 22th , 2018, Special Joint DMIP & NM Seminar, John Hopkins University.

5. “Hybrid collimator & detector SPECT design toward boosting sensitivity and resolution”, University at Sydney, November 19th 2018.

● PATENTS：

1. International Patents (PCT and Foreign Entries)

· WO2024093737A1 – Gamma Imaging Apparatus and Imaging Method, PCT application filed 2023.

· WO2022037473A1 – Collimator Unit, Detection Apparatus, and SPECT Imaging System, granted in US(US12228690),Russia (RU2808532C1), Japan (JP7520431B2), Australia (AU2021329704B2); under examination in US, EU, Korea, Canada.

· WO2020125371A1 – Gamma Radiation Imaging Device and Imaging Method, granted in US (US11644584B2), Canada, Japan, Australia, Russia; under examination in EU.

2. China Patents

· CN115685305A – Gamma Imaging Apparatus and Imaging Method (under examination).

· CN117518230A – Detector and Passive Neutron Source Imaging System and Method (under examination).

· CN114010211A – Gamma Camera and Imaging Method (under examination).

· CN114049298A – Close-range Nuclear Radiation Imaging Method and Apparatus (granted).

· CN113100795A – Gamma Detector and Real-time Imaging System and Method (under examination).

· CN113057664A – SPECT Imaging Apparatus (granted).

· CN113031046A – Nuclear Radiation Imaging Apparatus and Combined Imaging Method (granted).

· CN114690237A – Handheld Gamma Detection System and Apparatus (under examination).

· CN114076973A – Precise Localization Gamma Photon Detection Unit and Device (under examination).

· CN114076974A – Single Photon Emission Computed Tomography (SPECT) Device (granted).

· CN114076972A – Collimator Unit, Detection Apparatus, and SPECT Imaging System (granted).

· CN111329500A – Gamma Radiation Imaging Device and Imaging Method (granted).

PEER-REVIEWED PUBLICATIONS：

[1] Zhang D, Cheng L, Hu Y, Lyu Z, Wang L, Fang W, Yao R, Ma T. Design optimization and simulated performance evaluation of a self-collimated cardiac SPECT with simultaneous high sensitivity and resolution. Medical Physics. 2025, 52(6): 3823-39.

[2] Yu Z, Lyu Z, Fan P, Wu J, Liu Y, Ma T. Sub-Millimeter Pixelated SPECT Detector Using GAGG:Ce and Light Guide With Optical Barrier Slits. IEEE Transactions on Radiation and Plasma Medical Sciences. 2025:1-1.

[3] Zhang H, Zhao B, Fan P, Wang S, Lu W, Yu Y, Wu Z, Ma T, Liu H, Liu Y. Proton Range Verification Realized via a Multi-Slit Prompt Gamma Imaging System. IEEE Transactions on Radiation and Plasma Medical Sciences, 2025: 1-1.

[4] Xiao M, Song J, Lyu Z, Huang X, Zhang Y, Wang L, He Z, Ma T, Li C, Cao H, Zhang Q, Xiang C, Dong J. Regional Liver Function Assessment Using 99mTc-GSA SPECT/CT Scintigraphy in Malignant Perihilar Biliary Tumor Undergoing Major Liver Resection: A Dual-Center Cohort Study. Ann Surg Oncol, 2025.

[5] Liu L, Gong H, Yu Z, Fan P, Lyu Z, Xu T, Han Y, Liu Y, Ma T. Development of a high-resolution and omnidirectional field-of-view neutron imager. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2024;1061.

[6] Zhu YH, Lyu Z, Lu WZ, Liu YQ, Ma TY. Fast and Accurate Gamma Imaging System Calibration Based on Deep Denoising Networks and Self-Adaptive Data Clustering. SENSORS. 2023;23.

[7] Zhang D, Lyu Z, Liu Y, He ZX, Yao R, Ma T. Characterization and Assessment of Projection Probability Density Function and Enhanced Sampling in Self-Collimation SPECT. IEEE Transactions on Medical Imaging. 2023;42:2787-2801.

[8] Wang R, Zhang D, Hu Y, Lyu Z, Ma T. High-sensitivity cardiac SPECT system design with collimator-less interspaced mosaic-patterned scintillators. Frontiers in Medicine. 2023;10.

[9] Hu YF, Lyu Z, Fan P, Xu TP, Wang S, Liu YQ, Ma TY. A Wide Energy Range and 4 pi-View Gamma Camera with Interspaced Position-Sensitive Scintillator Array and Embedded Heavy Metal Bars. SENSORS. 2023;23.

[10] Wei QY, Lyu ZL, Jiang NM, Deng ZH, Xu TP, Sun LF, Zhang XF, He ZX, Liu YQ, Ma TY. Study of Tc-99m absorption on micro-sized ion exchange resins to achieve high activity for SPECT. Applied Radiation and Isotopes. 2022;186:5.

[11] Omidvari N, Cheng L, Leung EK, Abdelhafez YG, Badawi RD, Ma T, Qi J, Cherry SR. Lutetium background radiation in total-body PET-A simulation study on opportunities and challenges in PET attenuation correction. Frontiers in nuclear medicine (Lausanne, Switzerland). 2022;2.

[12] Lu WZ, Zhang DB, Fan P, Wang S, Wu ZX, Ma TY, Liu YQ. Simulation Study of a 3-D Multislit Prompt Gamma Imaging System for Proton Therapy Monitoring. IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES. 2022;6:355-365.

[13] Hu YF, Fan P, Lyu Z, Huang JW, Wang S, Xia Y, Liu YQ, Ma TY. Design and performance evaluation of a 4 pi-view gamma camera with mosaic-patterned 3D position-sensitive scintillators. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. 2022;1023.

[14] Wang R, Liu H, Toyonaga T, Shi LY, Wu J, Onofrey JA, Tsai YJ, Naganawa M, Ma TY, Liu YQ, Chen MK, Mecca AP, O'Dell RS, van Dyck CH, Carson RE, Liu C. Generation of synthetic PET images of synaptic density and amyloid from F-18-FDG images using deep learning. MEDICAL PHYSICS. 2021;48:5115-5129.

[15] Ma TY, Wei QY, Lyu Z, Zhang DB, Zhang HY, Wang R, Dong JH, Liu YQ, Yao RT, He ZX. Self-Collimating SPECT With Multi-Layer Interspaced Mosaic Detectors. IEEE Transactions on Medical Imaging. 2021;40:2152-2169.

[16] Zhang HY, Fan P, Wang S, Xia Y, Xu TP, Wei QY, Lu WZ, Wu ZX, Liu YQ, Ma TY. Design and Performance Evaluation of a BGO + SiPM Detector for High-Energy Prompt Gamma Imaging in Proton Therapy Monitoring. IEEE Transactions on Radiation and Plasma Medical Sciences. 2020;4:184-193.

[17] Wei Q, Ma T, Jiang N, Xu T, Lyu Z, Hu Y, Liu Y. A side-by-side LYSO/GAGG phoswich detector aiming for SPECT imaging. Nuclear Instruments Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors Associated Equipment. 2020:163242.

[18] Wei Q, Jiang N, Xu T, Lyu Z, Ma T, Liu Y. A position sensitive scintillation detector using a side-by-side GAGG-F/GAGG-T phoswich block. Journal of Instrumentation. 2020;15.

[19] Cheng L, Ma TY, Zhang XZ, Peng QY, Liu YQ, Qi JY. Maximum likelihood activity and attenuation estimation using both emission and transmission data with application to utilization of Lu-176 background radiation in TOF PET. MEDICAL PHYSICS. 2020;47:1067-1082.

[20] Ye Q, Fan P, Wang R, Lyu Z, Hu A, Wei Q, Xia Y, Yao R, Liu Y, Ma T. A high sensitivity 4π view gamma imager with a monolithic 3D position-sensitive detector. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2019;937:31-40.

[21] Lu WZ, Onofrey JA, Lu YH, Shi LY, Ma TY, Liu YQ, Liu C. An investigation of quantitative accuracy for deep learning based denoising in oncological PET. Physics in Medicine and Biology. 2019;64.

[22] Ye Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C. Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static F-18-FDG PET as a function of injected dose. Physics in Medicine and Biology. 2018;63.

[23] Wei Q, Xu T, Dai T, Wang S, Liu Y, Gu Y, Ma T. Development of a compact DOI-TOF detector module for high-performance PET systems. Nuclear Science and Techniques. 2017;28.

[24] Wei Q, Ma T, Xu T, Liu Y, Wang S, Gu Y. Evaluation of signal energy calculation methods for a light-sharing SiPM-based PET detector. Nuclear Instruments & Methods in Physics Research Section a-Accelerators Spectrometers Detectors and Associated Equipment. 2017;848:81-86.

[25] Wei QY, Ma TY, Wang S, Liu YQ, Gu Y, Dai TT. PET/CT alignment calibration with a non-radioactive phantom and the intrinsic Lu-176 radiation of PET detector. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2016;835:163-168.

[26] Wei QY, Dai TT, Ma TY, Liu YQ, Gu Y. Crystal Identification in Dual-Layer-Offset DOI-PET Detectors Using Stratified Peak Tracking Based on SVD and Mean-Shift Algorithm. IEEE Transactions on Nuclear Science. 2016;63:2502-2508.

[27] Fan P, Ma TY, Wei QY, Yao RT, Liu YQ, Wang S. Choice of crystal surface finishing for a dual-ended readout depth-of-interaction (DOI) detector. Physics in medicine and biology. 2016;61:1041-1056.

[28] Wei Q, Wang S, Ma T, Wu J, Liu H, Xu T, Xia Y, Fan P, Lyu Z, Liu Y. Performance evaluation of a compact PET/SPECT/CT tri-modality system for small animal imaging applications. Nuclear Instruments & Methods in Physics Research Section a-Accelerators Spectrometers Detectors and Associated Equipment. 2015;786:147-154.

[29] Liu H, Chan C, Grobshtein Y, Ma TY, Liu YQ, Wang S, Stacy MR, Sinusas AJ, Liu C. Anatomical-based partial volume correction for low-dose dedicated cardiac SPECT/CT. Physics in Medicine and Biology. 2015;60:6751-6773.

[30] Fan P, Hutton BF, Holstensson M, Ljungberg M, Pretorius PH, Prasad R, Ma TY, Liu YQ, Wang S, Thorn SL, Stacy MR, Sinusas AJ, Liu C. Scatter and crosstalk corrections for Tc-99m/I-123 dual-radionuclide imaging using a CZT SPECT system with pinhole collimators. Medical Physics. 2015;42:6895-6911.

[31] Yu Y H, Xia Y, Chen J, Hong B Y, Liu Y Q, Wang S, Ma T Y. PET image reconstruction with rotationally symmetric polygonal pixel grid based highly compressible system matrix. Nuclear Science and Techniques, 2013, 24(3).

[32] Xia Y, Yao R T, Deng X, Liu Y Q, Wang S, Ma T Y. Assessment of hybrid rotation-translation scan schemes for in vivo animal SPECT imaging. Physics in Medicine and Biology, 2013, 58(4): 965-83.

[33] Xia Y, Ma T Y, Liu Y Q, Sun X S, Wang S, Shao Y P. Imaging performance evaluation in depth-of-interaction PET with a new method of sinogram generation: A Monte Carlo simulation study. NUCLEAR SCIENCE AND TECHNIQUES, 2011, 22(3): 144-50.

[34] Wei Q Y, Wang S, Ma T Y, Ma F, Dai T T, Xu T P, et al. Influence factors of two dimensional position map on photomultiplier detector block designed by quadrant sharing technique. NUCLEAR SCIENCE AND TECHNIQUES, 2011, 22(4): 224-9.

[35] Dai T T, Ma T Y, Liu H, Cui J J, Wei Q Y, Liu Y Q, et al. A high-resolution small animal SPECT system developed at Tsinghua. NUCLEAR SCIENCE AND TECHNIQUES, 2011, 22(6): 344-8.

[36] Yao R T, Ma T Y, Shao Y P. Derivation of System Matrix from Simulation Data for an Animal SPECT With Slit-Slat Collimator. IEEE Transactions on Nuclear Science, 2009, 56(5): 2651-8.

[37] Ma T Y, Yao R T, Shao Y P, Zhou R. A SVD-Based Method to Assess the Uniqueness and Accuracy of SPECT Geometrical Calibration. IEEE Transactions on Medical Imaging, 2009, 28(12): 1929-39.

[38] Yao R T, Ma T Y, Shao Y P. Lutetium oxyorthosilicate (LSO) intrinsic activity correction and minimal detectable target activity study for SPECT imaging with a LSO-based animal PET scanner. Physics in Medicine and Biology, 2008, 53(16): 4399-415.

[39] Shao Y P, Yao R T, Ma T Y. A novel method to calibrate DOI function of a PET detector with a dual-ended-scintillator readout. Medical Physics, 2008, 35(12): 5829-40.

[40] Xu P, Ma T Y, Jin Y J. Entropy-based method to evaluate the data integrity. Nuclear Instruments and Methods in Physics Research Section a-Accelerators Spectrometers Detectors and Associated Equipment, 2006, 569(2): 412-5.

SELECTED CONFERENCE PRESENTATIONS：

[1] Fan, P., Z. Lyu, T. Xu, Y. Hu, Q. Wei, C. Zhu, L. Jiang, Y. Xia, Y. Liu and T. Ma (2019). Design and Development of a 3D Position-Sensitive Detector for 4π View Gamma Imager Based on Dual-Ended Readout Technique. 2019 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC): 1-4.

[2] Fan, P., S. Wang, Z. X. Wu, Y. Q. Liu, T. Y. Ma and Ieee (2017). Monolithic PET Detector Calibration Using Uncollimated Source and Gamma Interaction Position Distribution Constraint. 2017 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Atlanta, GA, IEEE.

[3] Guo, L., T. Ma, D. Zhang, Y. Hu, Y. Liu and R. Yao (2021). Design and simulations of a self-collimating whole-body SPECT system. SNMMI, Soc Nuclear Med.

[4] Hongyang, Z., F. Peng, W. Shi, X. Yan, X. Tianpeng, W. Qingyang, W. Zhaoxia, L. Yaqiang and M. Tianyu (2018). "Detector Development for Prompt Gamma Imaging in Proton Therapy Online Monitoring." 2018 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). Proceedings: 5 pp.-5 pp.

[5] Hu, Y., P. Fan, Z. Lyu, Y. Xia, S. Wang, Z. Wu, Y. Liu and T. Ma (2020). Imaging Performance Improvement of a 4π-View Gamma Imager Using 3D Position-Sensitive Interspaced Mosaic Detector. 2020 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[6] Hu, Y., P. Fan, Z. Lyu, T. Xu, C. Qi, Y. Liu and T. Ma (2022). A High-Sensitivity Mobile Gamma Camera with Mosaic-Patterned Scintillator-Glass Detector for Intraoperative Imaging Guidance. 2022 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[7] Hu, Y., S. Feng, P. Fan, D. Zhang, Z. Wu, S. Wang, Y. Liu, Y. Xia and T. Ma (2020). Design and Simulation Study of a MeV Astronomical Gamma-ray Telescope with Multilayer Spatial Separated Position-Sensitive Scintillation Detectors. 2020 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[8] Hu, Y., Z. Lyu, P. Fan, Y. Xia, S. Wang, Z. Wu, Y. Liu and T. Ma (2021). A High-Sensitivity and High-Resolution 4π-View Gamma Camera with Mosaic-Patterned 3D Position-Sensitive Scintillators. 2021 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[9] Hu, Y., Z. Lyu, P. Fan, T. Xu, Y. Liu and T. Ma (2022). Wide Energy Range and 4π-View Gamma Imaging with Interspaced

[10] Scintillator Array and Embedded Heavy Metal Bars. 2022 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[11] Hu, Y., Z. Lyu, P. Fan, T. Xu, Y. Liu and T. Ma (2022). Wide Energy Range and 4π-View Gamma Imaging with Interspaced Scintillator Array and Embedded Heavy Metal Bars. 2022 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[12] Hu, Y., Z. Lyu, P. Fan, T. Xu, C. Qi, Y. Liu and T. Ma (2022). A High-Sensitivity Mobile Gamma Camera with Mosaic-Patterned

[13] Scintillator-Glass Detector for Intraoperative Imaging Guidance. 2022 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[14] Hu, Y., X. Zheng, Z. Lyu, Y. Pan, Y. Liu, R. Yao and T. Ma (2023). Preliminary Performance Evaluation of a Hand-Held Magic-Cube Spectral Intraoperative Gamma Camera. 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD).

[15] Hu, Y. F., G. I. Angelis, P. L. Kench, O. K. Fuller, Y. Q. Liu, T. Y. Ma, S. R. Meikle and Ieee (2019). Direct Estimation of Neurotransmitter Activation Parameters in Dynamic PET Using Regression Neural Networks. 2019 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Manchester, ENGLAND, Ieee.

[16] Hui, L., W. Shi, M. Tianyu, W. Jing, C. Si, W. Qingyang, D. Tiantian and L. Yaqiang (2014). "Feasibility studies of a high sensitivity, stationary dedicated cardiac SPECT with multi-pinhole collimators on a clinical dual-head scanner." 2014 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC): 1-4.

[17] Juntang, Z., F. Peng, W. Xinqiang, W. Shi, L. Yaqiang, W. Zhaoxia and M. Tianyu (2015). An analytical model of optical photon transportation for monolithic PET detector. 2015 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC): 2 pp.-2 pp.

[18] Liu, H., J. Wu, W. Zhao, Y. Liang, X. Wang, S. Wang, Y. Liu and T. Ma (2016). Regularized MLEM Reconstrution with a Strong Anatomical Prior Using Newton Iterative Algorithm. 2016 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[19] Liu, L., Y. Hu, Z. Lyu, T. Xu, P. Fan, Y. Han, Y. Liu, Y. Xia and T. Ma (2022). 4π-view Neutron Imaging with a Mosaic-patterned

[20] GAGG(Ce)/Plastic Scintillator Block. 2022 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[21] Liu, X., T. P. Xu, Y. Xia, T. Y. Ma, Y. Q. Liu and Ieee (2017). A Novel TOF-PET Detector Based on SiPM and Cherenkov Radiation. 2017 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Atlanta, GA, Ieee.

[22] Lu, W. Z., P. Fan, H. Liu, Z. X. Wu, S. Wang, Y. Q. Liu, T. Y. Ma and Ieee (2016). Prompt Gamma Imaging with a Multi-Knife-Edge Slit Collimator for Large FOV Monitoring of Scanned Proton Pencil Beams. 2016 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Strasbourg, FRANCE, Ieee.

[23] Lu, W. Z., P. Fan, Y. Q. Liu, Z. X. Wu, S. Wang, T. Y. Ma and Ieee (2017). Characterization and Modeling of Knife-Edge Slit Collimator Response for MeV Prompt Gamma Photons in Proton Therapy Monitoring. 2017 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Atlanta, GA, Ieee.

[24] Lyu, Z., P. Fan, T. Xu, R. Wang, Y. Liu, S. Wang, Z. Wu and T. Ma (2019). Development and Performance Evaluation of a 4π View Radiation Imaging System. 2019 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC): 1-3.

[25] Lyu, Z. L., P. Fan, Y. Q. Liu, S. Wang, Z. X. Wu, T. Y. Ma and Ieee (2017). Timing Estimation Algorithm Incorporating Spatial Position for Monolithic PET Detector. 2017 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Atlanta, GA, Ieee.

[26] Lyu, Z. L., P. Fan, T. P. Xu, R. Wang, Y. Q. Liu, S. Wang, Z. X. Wu, T. Y. Ma and Ieee (2017). Improved Spatial Resolution and Resolution Uniformity of Monolithic PET Detector by Optimization of Photon detector Arrangement. 2017 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Atlanta, GA, IEEE.

[27] Lyu, Z. L., T. Y. Ma, H. P. Wang, S. Wang, Z. X. Wu and Y. Q. Liu (2018). "Initial design of a Large Animal Dynamic SPECT CT imaging system." Journal of Nuclear Medicine 59.

[28] Lyu, Z. L., S. Wang, H. P. Wang, H. Liu, L. Cheng, Z. X. Wu, Z. X. He, Y. Q. Liu, T. Y. Ma and Ieee (2018). Design and Initial Performance Evaluation of a Large-Animal Dynamic SPECT/CT Imaging System. 2018 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Sydney, AUSTRALIA, Ieee.

[29] Ma, T., P. Fan, W. Lu, H. Zhang, D. Zhang, Y. Xia, S. Wang and Y. Liu (2019). "Development of a prompt gamma imaging system with multi-slit collimator and BGO+ SiPM detector for proton therapy monitoring." Journal of Nuclear Medicine 60(supplement 1): 530-530.

[30] Ma, T. Y., Q. Ye, Z. L. Lyu, S. L. Yao, Y. Dong and Y. Q. Liu (2019). "Optimization of simplified acquisition protocols for FDG PET imaging with population-based input function." Journal of Nuclear Medicine 60.

[31] Peng, F., X. Tianpeng, L. Zhenlei, W. Shi, L. Yaqiang and M. Tianyu (2016). "3D positioning and readout channel number compression methods for monolithic PET detector." 2016 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC): 4 pp.-4 pp.

[32] Qing, Y., F. Peng, W. Qingyang, Y. Yunhan, W. Shi, L. Yaqiang and M. Tianyu (2016). "Collimator-less 4pi gamma imaging with 3-D position-sensitive detector." 2016 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC): 3 pp.-3 pp.

[33] Qiulin, W., C. Si, L. Xingdong, W. Kun, W. Shi, M. Tianyu and L. Yaqiang (2014). "Millisecond SPECT image reconstruction acceleration using OSEM algorithm based on CPU / GPU hybrid parallel hardware platform." 2014 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC): 1-4.

[34] Tianyu Ma, Q. Y., Zhenlei Lyu, Shulin Yao, Yun Dong, Yaqiang Liu (2018). Optimization of simplified acquisition protocols for FDG PET imaging with population-based input function. 2018 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging.

[35] Wang, R., Y. Hu, D. Zhang, Z. Lyu, L. Guo, Z.-x. He, L. Yaqiang and T. Ma (2021). High-sensitivity Cardiac SPECT System Design with Uncollimated Mosaic Detectors. 2021 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[36] Wang, R., H. Liu, Y. Hu, A.-K. Hu, X. Chen, Z. Lyu, Y. Liu and T. Ma (2022). A cross-radioactive-source System Matrix Generation Method for a 4pi View Gamma Imager Using Deep Learning. 2022 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[37] Wei, Q. Y., T. T. Dai, T. Y. Ma, T. P. Xu, Y. Gu, Y. Q. Liu and Ieee (2017). Crystal identification for a dual-layer-offset LYSO based PET system via Lu-176 background radiation. 2017 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Atlanta, GA, Ieee.

[38] Wei, Q. Y., S. Wang, T. T. Dai, D. H. Li, T. P. Xu, N. M. Jiang, F. He, Y. J. Jin, T. Y. Ma, Y. Q. Liu and Ieee (2014). SiPM based PET Detector Modules with Air-Gapped Pixelated LYSO. 2014 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Seattle, WA, Ieee.

[39] Wei, Q. Y., S. Wang, T. T. Dai, T. Y. Ma, H. Liu, J. Wu, N. M. Jiang, Z. X. Wu, Y. Q. Liu and Ieee (2014). Geometrical Calibration of a PET-scanner-based Multi-pinhole SPECT Using LYSO Background Radiation. 2014 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Seattle, WA, Ieee.

[40] Wu, J., T. Y. Ma, H. Liu, J. C. Liang, S. Wang, Y. Q. Liu, J. P. Cheng and Ieee (2014). Studies of DOI estimation method in LOR data for 3D PET list-mode reconstruction. 2014 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Seattle, WA, Ieee.

[41] Xiong, X., S. Wang, S. Chen, H. Liu, J. J. Wu, Y. Q. Liu, T. Y. Ma and Ieee (2014). CT Image Resolution Improvement by Geometric Modelling in Iterative Reconstruction. 2014 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Seattle, WA, Ieee.

[42] Xu, T. P., S. Wang, Q. Y. Wei, W. L. Liu, G. H. Gong, Z. Deng, T. Y. Ma, Y. Q. Liu and Ieee (2014). Development of Multi-Channel Fast SiPM Readout Electronics for Clinical TOF PET Detector. 2014 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Seattle, WA, Ieee.

[43] Xu, T. P., Q. Y. Wei, G. H. Gong, Y. G. Liu, T. Y. Ma and Ieee (2016). Development of a MR-compatible DOI-TOF Detector Module for PHT Imaging Systems. 2016 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Strasbourg, FRANCE, IEEE.

[44] Ye, Q., Z. L. Lyu, S. L. Yao, Y. Dong, H. Liu, J. Wu, Y. Q. Liu, T. Y. Ma and Ieee (2018). Direct 4D Patlak Reconstruction in Dynamic FDG PET Imaging with Population-based Input Function. 2018 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Sydney, AUSTRALIA, Ieee.

[45] Ye, Q., T. Y. Ma, S. L. Yao, Y. H. Yu, S. Wang and Y. Q. Liu (2018). "Voxel-based dynamic FDG PET with simplified data acquisition protocols and shortened scan duration." Journal of Nuclear Medicine 59.

[46] Yu, Y., W. Shi, W. Xinqiang, X. Yan, S. Hong, W. Jing, W. Qiulin, L. Yaqiang and M. Tianyu (2014). Impact of depth-of-interaction on image resolution in long axial-FOV PET. 2014 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC): 1-4.

[47] Yu, Y. H., C. Chan, T. Y. Ma, Y. Q. Liu, J. D. Gallezot, M. Naganawa, O. J. Kelada, M. Germino, A. J. Sinusas, R. E. Carson and C. Liu (2016). "Event-by-Event Continuous Respiratory Motion Correction for Dynamic PET Imaging." Journal of Nuclear Medicine 57(7): 1084-1090.

[48] Yu, Y. H., S. L. Yao, W. Shi, Y. Q. Liu, T. Y. Ma and Ieee (2016). PET-MR Joint Reconstruction with Information Theoretic Priors. 2016 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Strasbourg, FRANCE, Ieee.

[49] Zhang, D., Z. Lyu, T. Xu, P. Fan, Z. Yu, Q. Wei, Z. X. He, Y. Liu and T. Ma (2023). Development and Performance Evaluation of an Ultra-High-Resolution Self-Collimation SPECT System for Small Animal Imaging. 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD).

[50] Zhang, D., X. Zheng, Y. Hu, Z. Lyu, Z.-X. He, Y. Liu, R. Yao and t. ma (2022). "Feasibility study of a self-collimating SPECT for fast dynamic cardiac imaging." Journal of Nuclear Medicine 63(supplement 2): 2338.

[51] Zhang, D. B., P. Fan, W. Z. Lu, S. Wang, Y. Xia, Z. X. Wu, Y. Q. Liu, T. Y. Ma and Ieee (2018). Accurate Modeling of Multi Knife-edge Slit Collimator System Response for MeV Prompt Gamma Photons in Proton Therapy Monitoring. 2018 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Sydney, AUSTRALIA, IEEE.

[52] Zhang, D. B., T. Y. Ma, Z. L. Lv, Q. Y. Wei, T. P. Xu, H. Y. Zhang, R. T. Yao, Y. Q. Liu and Z. X. He (2020). "Design and performance evaluation of a self-collimating SPECT system for small animal imaging." Journal of Nuclear Medicine 61.

[53] Zhang, H., B. Zhao, Z. Wang, P. Fan, S. Wang, Z. Wu, T. Ma and Y. Liu (2023). 3D Prompt Gamma Imaging in a Dual-head Multi-slit System for Proton Beam Range Monitoring. 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD).

[54] Zhang, H. Y., P. Fan, T. P. Xu, Q. Wei, T. Y. Ma, Y. Q. Liu, Z. X. Wu and Ieee (2017). Scintillation Detector Design Study for Prompt Gamma Photon Detection in Proton Therapy Monitoring. 2017 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Atlanta, GA, Ieee.

[55] Zheng, X., T. Xu, Z. Lyu and T. Ma (2022). Development of a Self-collimating Gamma Camera with ultra-high resolution. 2022 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[56] Zhenlei, L., C. Si, W. Xinqiang, G. Lilei, W. Shi, M. Tianyu and L. Yaqiang (2014). "A maximum likelihood gamma positioning method with accurate calibration of the mean detector response function in a clinical SPECT detector." 2014 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC): 1-4.

[57] Zhu, Y., W. Lu, Z. Lyu, L. Wang, Y. Hu, Z. Wu, S. Wang, Y. Liu and T. Ma (2020). Fast System Matrix Calibration for a 4π View Gamma Imager with a Deep Learning Based Denoising Approach. 2020 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[58] Zhu, Y., Z. Lyu, R. Yao and T. Ma (2023). A High Sensitivity Mechanical-collimator-free Magic-brush Brain SPECT. 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD).

[59] Zhu, Y., D. Zhang, Y. Hu, Z. Lyu, Y. Liu, R. Yao and T. Ma (2022). Collimator-less Single-Slim-Detector SPECT. 2022 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[60] Zhuang, J. T., P. Fan, X. Q. Wang, S. Wang, Y. Q. Liu, Z. X. Wu, T. Y. Ma and Ieee (2015). An Analytical Model of Optical Photon Transportation for Monolithic PET Detector. 2015 IEEE, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), San Diego, CA, Ieee.

● Public Service appointments：

2025, Topic Convener, IEEE NSS/MIC conference.

2024 - present, Editorial Board Member, Scientific Reports.

2023, Topic Convener, IEEE NSS/MIC conference.

2021, Topic Convener and Session Chair, IEEE NSS/MIC conference.

2020 - present, Associate Editor, IEEE Transactions on Medical Imaging.

2020 - present, Physicist and Technician Group Member, Nuclear Medicine Branch, Beijing Medical Society.

2018, Editorial board, Chinese Journal of Stereology and Image Analysis.

● Professional Associations：

Member, IEEE NPSS

Member, SNMMI

Member, Nuclear medicine branch, China Nuclear Society

Member, China association of medical equipment

Member of Physicist and Technician Group, Nuclear Medicine Branch, Beijing Medical Society.

● Review activities for Scientific Journals：

IEEE Transactions on Medical Imaging；

Medical Physics；

Physics in Medicine and Biology；

IEEE Transactions on Radiation and Plasma Medical Sciences；

Nuclear Science and Technology；

Chinese Physics B；

Mathematical Methods and Applications in Medical Imaging；

Biomedical and Environmental Sciences；

Nuclear Inst. and Methods in Physics Research, A；

Chinese Journal of Physics；

Computer Methods and Programs in Biomedicine；

Radiation Physics and Chemistry.

● Review activities for Scientific Meetings：

IEEE Symposium of Nuclear Science and Medical Imaging Conference；

BioMedical Engineering and Informatics；

International Conference on Biomedical Engineering and Biotechnology.

● Academic Honors and Awards：

Gold Award, 50th Geneva International Exhibition of Inventions, Ultra High Resolution Nuclear Medicine Imaging With Innovative Self-Collimation Technology, 2025.

Outstanding innovation Award and Gold Award, 49th Geneva International Exhibition of Inventions, An Intraoperative Handheld Medical Gamma Camera Based On Self-Collimating Technology, 2024.

● Teaching Honors and Awards：

Beijing Excellent Mentor Award of Undergraduate Project, 2019.

Annual Excellent Teaching Award, Tsinghua University, 2016.

Annual Excellent Teaching Award, Tsinghua University, 2017.

Winner of 6th Young Professionals Teaching Competition, First Price, Tsinghua University, 2015.

● Mentee Honors and Awards：

1. Mentor of Best Ph.D. Dissertation in Tsinghua University (top 5%), “Study on Self-Collimation Gamma Imaging Based on Sparse Array Three-Dimensional Position-Sensitive Detectors”, Yifan Hu.

2. Mentor of Best Oral Paper Candidate, NSS Oral Presentation “Development of a Super High Resolution Self-Collimating Industrial Gamma Camera” in IEEE NSS/MIC 2024. (presenter: Linxin Lei)

3. Mentor of Honorary Mention, Physics Instrumentation & Data Sciences Council Young Investigator Award in SNMMI 2024. (presenter: Xingchun Zheng)

4. Mentor of Best Oral Paper (1st place), MIC Oral Presentation “Preliminary Performance Evaluation of a Hand-Held Magic-Cube Spectral Intraoperative Gamma Camera” in IEEE NSS/MIC 2023. (presenter: Yifan Hu)

5. Mentor of Best Oral Paper (2nd place), MIC Oral Presentation “Development and Performance Evaluation of an Ultra-High-Resolution Self-Collimation SPECT System for Small Animal Imaging” in IEEE NSS/MIC 2023. (presenter: Debin Zhang)

6. Mentor of Best Oral Paper (1st place), NSS Oral Presentation “A High-Sensitivity and Mentor of Best Oral Paper (3rd place), MIC Poster Presentation “Collimator-less Single-Slim-Detector SPECT” in IEEE NSS/MIC 2022. (presenter: Yihang Zhu)

7. High-Resolution 4π-View Gamma Camera with Mosaic-Patterned 3D Position-Sensitive Scintillators” in IEEE NSS/MIC 2021. (presenter: Yifan Hu)

8. Mentor of Best Oral Paper Candidate, NSS Oral Presentation “High-sensitivity Cardiac SPECT System Design with Uncollimated Mosaic Detectors” in IEEE NSS/MIC 2022. (presenter: Rui Wang)

9. Mentor of University-Level Excellence Award in Undergraduate Thesis Training, 2025, awarded to Jincheng Wang, Tsinghua University.110. Mentor of University-Level Excellence Award in Undergraduate Thesis Training, 2024, awarded to Yuxi Zhang, Tsinghua University.

11. Mentor of Beijing Municipal Outstanding Undergraduate Thesis Award and University-Level Excellence Award in Undergraduate Thesis Training, 2023, awarded to Peize Li, Tsinghua University.

12. Mentor of University-Level Excellence Award in Undergraduate Thesis Training, 2022, awarded to Linxin Lei, Tsinghua University.

13.Mentor of Department-Level Excellence Award in Undergraduate Thesis Training, 2021, awarded to Xingchun Zheng, Tsinghua University.

14. Mentor of Department-Level Excellence Award in Undergraduate Thesis Training, 2021, awarded to Yihang Zhu, Tsinghua University.

15. Mentor of Beijing Municipal Outstanding Undergraduate Thesis Award and University-Level Excellence Award in Undergraduate Thesis Training, 2019, awarded to Yifan Hu, Tsinghua University.

16. Mentor of Department-Level Excellence Award in Undergraduate Thesis Training, 2020, awarded to Debin Zhang, Tsinghua University.17. Mentor of University-Level Excellence Award in Undergraduate Thesis Training, 2020, awarded to Rui Wang, Tsinghua University.